IMPORTANT: Advance notice of update to IRAS v5.9 – information for users about expected system availability.  
IRAS will not be available to users between 18.30-21.30 BST on Thursday 28 June 2018 while the update takes place. IRAS v5.9 will enable a single electronic submission of the IRAS Form for all research conducted in NHS/HSC that is led from Northern Ireland, Scotland or Wales. Please see the UK-wide working page for more information about this change. This release also includes some minor revisions to on screen guidance and an update of NHS/HSC organisation codes. Electronic authorisations will not be affected by this update.

IMPORTANT: Information for applicants with NHS sites in Wales. 
On 16 April 2018 Health and Care Research Wales implemented an interim step to align its processes and paperwork so that there is consistency across England and Wales for researchers. As part of this change, researchers starting new applications in IRAS no longer use NHS Site Specific Information (SSI) forms for NHS sites in Wales. See the Health and Care Research Wales website for further details. 

IMPORTANT: Information for applicants to ARSAC.
On 6 February 2018 the Administration of Radioactive Substances Advisory Committee (ARSAC) changed the way it grants approvals for research. Please refer to ARSAC website for details

25 May 2018: General Data Protection Regulation (GDPR) updates.  Guidance, including question specific guidance, has been updated, where applicable. Updates include explanations to bring questions in line with GDPR. Further changes may be made as new information emerges. For more information, applicants should refer to the HRA's GDPR guidance for the health and social care research sector.

18 April 2018: IRAS updated to v5.8. This version includes a substantive revision of the MHRA Devices application form and introduction of new 'verification tool' functionality in the IRAS Form. Applicants are strongly recommended to refer to the Updates page for more information about how this version release may have affected your existing project(s).

1 March 2018: mCTA and CRO-mCTA available in IRAS. Updated versions of the model agreements for commercially sponsored research in the NHS/HSC (mCTA and CRO-mCTA) have been published in the "Templates for supporting documents" section of IRAS. The templates are for use across the whole of the UK.
1 February 2018: IRAS updated to v5.7. This version adds organisational look-up data for NHS/HSC sites in Northern Ireland, Scotland and Wales. In addition revisions have been made to the dataset, guidance and declarations to reflect the recent publication of the UK Policy Framework for Health & Social Care Research. These revisions affect some electronic authorisations. Applicants are strongly recommended to refer to the Updates page for more information about how this version release may have affected your existing project(s).

The Integrated Research Application System (IRAS):
  • Is a single system for applying for the permissions and approvals for health and social care / community care research in the UK
  • Enables you to enter the information about your project once instead of duplicating information in separate application forms
  • Uses filters to ensure that the data collected and collated is appropriate to the type of study, and consequently the permissions and approvals required
  • Helps you to meet regulatory and governance requirements
IRAS captures the information needed for the relevant approvals from the following review bodies:
  • Administration of Radioactive Substances Advisory Committee (ARSAC)
  • Confidentiality Advisory Group (CAG)
  • Gene Therapy Advisory Committee (GTAC)
  • Health Research Authority (HRA) for projects seeking HRA Approval
  • Medicines and Healthcare products Regulatory Agency (MHRA)
  • NHS / HSC R&D offices
  • NHS / HSC Research Ethics Committees
  • Her Majesty's Prison and Probation Service (HMPPS)
  • Social Care Research Ethics Committee
Please help us to improve IRAS by sending your feedback to iras.queries@nhs.net. Your comments and suggestions will be included in the next review of the system.
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IRAS Integrated Research Application System, version 5.8.0, 18/04/2018, IRAS Dataset version 3.5.
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