Coronavirus / COVID-19 - key guidance

25 May 2021: IRAS updated to v5.20. This version includes updates to the MHRA Devices application to reflect the implementation of the EU Medical Devices Regulation in Northern Ireland. It includes changes to enabling of the form, questions, questions specific guidance and declarations / electronic authorisations.
 Please refer to the Updates page for more information.

09 March 2021: IRAS updated to v5.19. This version updates the wording of question A53 (how participants will be informed of results of research) and enables question A14-1 (public involvement in research) for all research studies. Please refer to the Updates page for more information.

21 December 2020: IRAS updated to v5.18. This version includes updates to questions and question specific guidance for studies involving medical devices. Please refer to the Updates page for more information.

The Integrated Research Application System (IRAS):
  • Is a single system for applying for the permissions and approvals for health and social care / community care research in the UK
  • Enables you to enter the information about your project once instead of duplicating information in separate application forms
  • Uses filters to ensure that the data collected and collated is appropriate to the type of study, and consequently the permissions and approvals required
  • Helps you to meet regulatory and governance requirements
IRAS captures the information needed for the relevant approvals from the following review bodies:
  • Administration of Radioactive Substances Advisory Committee (ARSAC)
  • Confidentiality Advisory Group (CAG)
  • Gene Therapy Advisory Committee (GTAC)
  • Health Research Authority (HRA) and Health and Care Research Wales (HCRW) for projects seeking HRA & HCRW Approval
  • Medicines and Healthcare products Regulatory Agency (MHRA)
  • NHS / HSC R&D offices
  • NHS / HSC Research Ethics Committees
  • Her Majesty's Prison and Probation Service (HMPPS)
  • Social Care Research Ethics Committee
Please help us to improve IRAS by sending your feedback to iras.queries@hra.nhs.uk. Your comments and suggestions will be included in the next review of the system.
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IRAS Integrated Research Application System, version 5.20, 25/05/2021, IRAS Dataset version 3.5.
The Health Research Authority (HRA) acknowledges the Integrated Research Application System (IRAS) partners in developing IRAS content. © Health Research Authority 2021.
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