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IMPORTANT: Advance notice of update to IRAS v5.7 – information for users about expected system availability and effect on electronic authorisations.
IRAS will not be available to users from 18.30-21.30 GMT on Tuesday 30 January 2018 while this update takes place. IRAS v5.7 includes an update that will affect electronic authorisations for some form types. Please refer to the Updates page for information on how this version release may impact your existing project(s).

IMPORTANT: Information for applicants to ARSAC.
From 6 February 2018 the Administration of Radioactive Substances Advisory Committee (ARSAC) will change the way it grants approvals for research. In preparation for these changes, ARSAC have released deadlines for some types of applications. Please refer to ARSAC website for details


18 October 2017: IRAS updated to v5.6. This version includes an update of prison establishments within the HMPPS (formerly NOMS) form and implements improvements to form checklist functionality, including addition of a multiple file upload feature for e-submitting form types. Applicants are recommended to refer to the Updates page for full details of this update. The Supported Browsers statement also comes into effect with this release.

28 June 2017: IRAS updated to v5.5. This version makes the IRAS Form available UK-wide so that new projects can use this form to seek NHS/HSC R&D Permission and REC review (if required) when project is led from Northern Ireland, Scotland or Wales. The release also includes updates to ODS code look-up in Part C and duplicate project functionality as well as revisions to guidance and some maintenance updates. Applicants are recommended to refer to the Updates page for detailed information.

8 March 2017: IRAS updated to v5.4.2. This version includes revisions to some embedded guidance and some maintenance updates. Electronic authorisations have not been affected by this update. Please refer to the Updates page for more information.


The Integrated Research Application System (IRAS):
  • Is a single system for applying for the permissions and approvals for health and social care / community care research in the UK
  • Enables you to enter the information about your project once instead of duplicating information in separate application forms
  • Uses filters to ensure that the data collected and collated is appropriate to the type of study, and consequently the permissions and approvals required
  • Helps you to meet regulatory and governance requirements
IRAS captures the information needed for the relevant approvals from the following review bodies:
  • Administration of Radioactive Substances Advisory Committee (ARSAC)
  • Confidentiality Advisory Group (CAG)
  • Gene Therapy Advisory Committee (GTAC)
  • Health Research Authority (HRA) for projects seeking HRA Approval
  • Medicines and Healthcare products Regulatory Agency (MHRA)
  • NHS / HSC R&D offices
  • NHS / HSC Research Ethics Committees
  • Her Majesty's Prison and Probation Service (HMPPS)
  • Social Care Research Ethics Committee
Please help us to improve IRAS by sending your feedback to iras.queries@nhs.net. Your comments and suggestions will be included in the next review of the system.
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IRAS Integrated Research Application System, version 5.6.1, 03/11/2017, IRAS Dataset version 3.5.
The Health Research Authority (HRA) acknowledges the Integrated Research Application System (IRAS) partners in developing IRAS content. © Health Research Authority 2018.
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