7 September 2016: IRAS updated to v5.3.2. This version includes removal of the function to create new minimal dataset projects, addition of a field to the non-CTIMP Notice of Substantial Amendment form, a new question in the project filter and functionality for creation of ARSAC site forms in projects seeking HRA Approval. This version also includes some minor updates to embedded guidance and some maintenance updates. Applicants are recommended to refer to the Updates page for more information.

7 June 2016: IRAS updated to v5.3.1. This version is primarily a maintenance release; however it also includes some minor updates to embedded guidance, removal of question A6-3 and an update affecting ARSAC applications. Applicants are recommended to refer to the Updates page for more information.

20 May 2016: IRAS e-learning module updated. The revised module, which is free to use and provides an overview of the functionality in IRAS, can be accessed via the horizontal toolbar at the top of this page.


The Integrated Research Application System (IRAS):
  • Is a single system for applying for the permissions and approvals for health and social care / community care research in the UK
  • Enables you to enter the information about your project once instead of duplicating information in separate application forms
  • Uses filters to ensure that the data collected and collated is appropriate to the type of study, and consequently the permissions and approvals required
  • Helps you to meet regulatory and governance requirements
IRAS captures the information needed for the relevant approvals from the following review bodies:
  • Administration of Radioactive Substances Advisory Committee (ARSAC)
  • Confidentiality Advisory Group (CAG)
  • Gene Therapy Advisory Committee (GTAC)
  • Health Research Authority (HRA) for projects seeking HRA Approval
  • Medicines and Healthcare products Regulatory Agency (MHRA)
  • NHS / HSC R&D offices
  • NHS / HSC Research Ethics Committees
  • National Offender Management Service (NOMS)
  • Social Care Research Ethics Committee
Please help us to improve IRAS by sending your feedback to iras.queries@nhs.net. Your comments and suggestions will be included in the next review of the system.
Please Login

First time and new users please click here.

  (Your full e-mail address)

Forgotten Password? Click here

* Passwords are case sensitive.

Quick Links
 Getting started

The Integrated Research Application System uses .pdf files to print. You need to have the free Adobe PDF Reader installed on your computer.
Click here to download the Adobe Reader

If you have difficulty installing this software please contact your computer administrator.

IRAS Integrated Research Application System, version 5.3.2, 07/09/2016, IRAS Dataset version 3.5.
The Health Research Authority (HRA) acknowledges the Integrated Research Application System (IRAS) partners in developing IRAS content. © Health Research Authority 2016.
Copyright and other intellectual property rights in the content of the Integrated Research Application System (IRAS) belong to the HRA and all rights are reserved. Terms & Conditions, Privacy Policy.