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IMPORTANT: Advance notice of essential maintenance work scheduled for Wednesday 25 September – information for users about expected system availability.
IRAS will not be available to users from 19.00 to 23.00 BST Wednesday 25 September 2019 while essential system maintenance work is carried out.


22 July 2019: IRAS updated to v5.13. This version includes a minor update to the REC Form checklist and some minor revisions and addition of question specific guidance for questions that are enabled for studies involving adults with incapacity in Northern Ireland. Electronic authorisations have not been affected by this update. Please refer to the Updates page for more information.

4 June 2019: IRAS updated to v5.12. This version update supports the implementation of changes related to UK-wide requirements for information related to participating NHS/HSC and non-NHS/non-HSC organisations. These changes mean that site specific information (SSI) forms will no longer be used and so this IRAS update removes the functionality to create SSIs. Applicants should refer to the Updates page for more information about this version release.

19 February 2019: IRAS updated to v5.11. This version update enables electronic submission of the application to MHRA Devices for clinical investigations of medical devices. Applicants should to refer to the Updates page for more information about this version release.

 13 December 2018: IRAS updated to v5.10. This update is a maintenance release that includes some updates to reference data and minor edits of embedded text. Please refer to the Updates page for more information.


The Integrated Research Application System (IRAS):
  • Is a single system for applying for the permissions and approvals for health and social care / community care research in the UK
  • Enables you to enter the information about your project once instead of duplicating information in separate application forms
  • Uses filters to ensure that the data collected and collated is appropriate to the type of study, and consequently the permissions and approvals required
  • Helps you to meet regulatory and governance requirements
IRAS captures the information needed for the relevant approvals from the following review bodies:
  • Administration of Radioactive Substances Advisory Committee (ARSAC)
  • Confidentiality Advisory Group (CAG)
  • Gene Therapy Advisory Committee (GTAC)
  • Health Research Authority (HRA) for projects seeking HRA Approval
  • Medicines and Healthcare products Regulatory Agency (MHRA)
  • NHS / HSC R&D offices
  • NHS / HSC Research Ethics Committees
  • Her Majesty's Prison and Probation Service (HMPPS)
  • Social Care Research Ethics Committee
Please help us to improve IRAS by sending your feedback to iras.queries@nhs.net. Your comments and suggestions will be included in the next review of the system.
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IRAS Integrated Research Application System, version 5.13, 22/07/2019, IRAS Dataset version 3.5.
The Health Research Authority (HRA) acknowledges the Integrated Research Application System (IRAS) partners in developing IRAS content. © Health Research Authority 2019.
Copyright and other intellectual property rights in the content of the Integrated Research Application System (IRAS) belong to the HRA and all rights are reserved. Terms & Conditions, Privacy Policy.