Welcome to the Integrated Research Application System (IRAS)

IMPORTANT: Advance notice of update to IRAS v5.0 – information for users about content of the release and expected system availability during update. 
IRAS will not be available between 19.00 - 22.00 BST on Sunday 9 August 2015 while the update takes place.
This release will include the addition of a new combined form for projects applying for HRA Approval and a revision to A68-2 (enabled in projects that are eligible or potentially eligible for NIHR CRN portfolio). All users should go to the Updates page for further information.

11 May 2015: HRA Approval now available for health services research studies in England involving NHS staff as participants. HRA Approval, which is the new approval that will be required for research to commence in the NHS in England, is being implemented in phases. From today, studies within the scope of the first phase may apply through this new process. Please refer to the guidance for applicants on the HRA website for more information.

1 April 2015: IRAS updated to v4.0.  This version includes revision to the statements in the Sponsor declaration, which affects e-authorisations for this declaration. It also includes: improvements to the My Projects page, change to password requirements, changes to IRAS project filter defaults, and references to ‘NIGB’ have been updated to ‘CAG’. Please refer to Updates for more information.

23 February 2015: IRAS updated to v3.5.5. This version includes minor updates to some guidance and revises the terms & conditions and privacy policy for the IRAS. It does not affect existing projects or user accounts. More information is provided in Updates.

The Integrated Research Application System (IRAS):
  • Is a single system for applying for the permissions and approvals for health and social care / community care research in the UK
  • Enables you to enter the information about your project once instead of duplicating information in separate application forms
  • Uses filters to ensure that the data collected and collated is appropriate to the type of study, and consequently the permissions and approvals required
  • Helps you to meet regulatory and governance requirements
IRAS captures the information needed for the relevant approvals from the following review bodies:
  • Administration of Radioactive Substances Advisory Committee (ARSAC)
  • Gene Therapy Advisory Committee (GTAC)
  • Medicines and Healthcare products Regulatory Agency (MHRA)
  • NHS / HSC R&D offices
  • NRES/ NHS / HSC Research Ethics Committees
  • Confidentiality Advisory Group (CAG)
  • National Offender Management Service (NOMS)
  • Social Care Research Ethics Committee
Please help us to improve IRAS by sending your feedback to iras.queries@nhs.net. Your comments and suggestions will be included in the next review of the system.


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IRAS Integrated Research Application System, version 4.0.0, 02/04/2015, IRAS Dataset version 3.5.
The Health Research Authority (HRA) acknowledges the Integrated Research Application System (IRAS) partners in developing IRAS content. © Health Research Authority 2015.
Copyright and other intellectual property rights in the content of the Integrated Research Application System (IRAS) belong to the HRA and all rights are reserved. Terms & Conditions, Privacy Policy.