IMPORTANT: Information for applicants to ARSAC.
On 6 February 2018 the Administration of Radioactive Substances Advisory Committee (ARSAC) changed the way it grants approvals for research. Please refer to ARSAC website for details

1 March 2018: mCTA and CRO-mCTA available in IRAS. Updated versions of the model agreements for commercially sponsored research in the NHS/HSC (mCTA and CRO-mCTA) have been published in the "Templates for supporting documents" section of IRAS. The templates are for use across the whole of the UK.

1 February 2018: IRAS updated to v5.7. This version adds organisational look-up data for NHS/HSC sites in Northern Ireland, Scotland and Wales. In addition revisions have been made to the dataset, guidance and declarations to reflect the recent publication of the UK Policy Framework for Health & Social Care Research. These revisions affect some electronic authorisations. Applicants are strongly recommended to refer to the Updates page for more information about how this version release may have affected your existing project(s).

18 October 2017: IRAS updated to v5.6. This version includes an update of prison establishments within the HMPPS (formerly NOMS) form and implements improvements to form checklist functionality, including addition of a multiple file upload feature for e-submitting form types. Applicants are recommended to refer to the Updates page for full details of this update. The Supported Browsers statement also comes into effect with this release.

28 June 2017: IRAS updated to v5.5. This version makes the IRAS Form available UK-wide so that new projects can use this form to seek NHS/HSC R&D Permission and REC review (if required) when project is led from Northern Ireland, Scotland or Wales. The release also includes updates to ODS code look-up in Part C and duplicate project functionality as well as revisions to guidance and some maintenance updates. Applicants are recommended to refer to the Updates page for detailed information.

The Integrated Research Application System (IRAS):
  • Is a single system for applying for the permissions and approvals for health and social care / community care research in the UK
  • Enables you to enter the information about your project once instead of duplicating information in separate application forms
  • Uses filters to ensure that the data collected and collated is appropriate to the type of study, and consequently the permissions and approvals required
  • Helps you to meet regulatory and governance requirements
IRAS captures the information needed for the relevant approvals from the following review bodies:
  • Administration of Radioactive Substances Advisory Committee (ARSAC)
  • Confidentiality Advisory Group (CAG)
  • Gene Therapy Advisory Committee (GTAC)
  • Health Research Authority (HRA) for projects seeking HRA Approval
  • Medicines and Healthcare products Regulatory Agency (MHRA)
  • NHS / HSC R&D offices
  • NHS / HSC Research Ethics Committees
  • Her Majesty's Prison and Probation Service (HMPPS)
  • Social Care Research Ethics Committee
Please help us to improve IRAS by sending your feedback to iras.queries@nhs.net. Your comments and suggestions will be included in the next review of the system.
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IRAS Integrated Research Application System, version 5.7.0, 01/02/2018, IRAS Dataset version 3.5.
The Health Research Authority (HRA) acknowledges the Integrated Research Application System (IRAS) partners in developing IRAS content. © Health Research Authority 2018.
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