Welcome to the Integrated Research Application System (IRAS) 

IMPORTANT: Advance notice of update to IRAS v4.0 – information for users about expected system availability and impact on electronic authorisations.

IRAS will not be available to users from 06.00-06.30 BST on Wednesday 01 April 2015 while the update takes place. IRAS v4.0 will include a revision to statements in the Sponsor declaration and so electronic authorisations for this declaration will be affected by this IRAS update. All users should go to the Updates page for information on how the update will impact your existing project(s).


23 February 2015: IRAS updated to v3.5.5. This version includes minor updates to some guidance and revises the terms & conditions and privacy policy for the IRAS. It does not affect existing projects or user accounts. More information is provided in Updates.

30 September 2014: Terms of the Sponsor declaration have been updated to include a statement that clinical trials have been registered. More information on this change is provided in Updates 19 May 2014: REC and non-NHS SSI forms are now electronically submitted. This change accompanies other changes to the REC application process, including how applications are booked. Please refer to the HRA website and Updates page for more information.


The Integrated Research Application System (IRAS):
  • Is a single system for applying for the permissions and approvals for health and social care / community care research in the UK
  • Enables you to enter the information about your project once instead of duplicating information in separate application forms
  • Uses filters to ensure that the data collected and collated is appropriate to the type of study, and consequently the permissions and approvals required
  • Helps you to meet regulatory and governance requirements
IRAS captures the information needed for the relevant approvals from the following review bodies:
  • Administration of Radioactive Substances Advisory Committee (ARSAC)
  • Gene Therapy Advisory Committee (GTAC)
  • Medicines and Healthcare products Regulatory Agency (MHRA)
  • NHS / HSC R&D offices
  • NRES/ NHS / HSC Research Ethics Committees
  • Confidentiality Advisory Group (CAG), formerly the National Information Governance Board (NIGB)
  • National Offender Management Service (NOMS)
  • Social Care Research Ethics Committee
Please help us to improve IRAS by sending your feedback to iras.queries@nhs.net. Your comments and suggestions will be included in the next review of the system.


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IRAS Integrated Research Application System, version 3.5.5, 17/02/2015, IRAS Dataset version 3.5.
The Health Research Authority (HRA) acknowledges the Integrated Research Application System (IRAS) partners in developing IRAS content. © Health Research Authority 2015.
Copyright and other intellectual property rights in the content of the Integrated Research Application System (IRAS) belong to the HRA and all rights are reserved. Terms & Conditions, Privacy Policy.